Better Bone Integration and Faster Healing: Next-Generation Biomaterials


Thursday, June 17 | 10:00 am - 10:45 am


Tech Center


All Levels

Participant Type:

Product Development, Manufacturing, Quality/Regulatory

Orthopedics has emphasized understanding of surface properties as greater attention has been placed on the biological response between patients and implant materials or structures. This focus is leading to a new generation of materials that seeks to facilitate faster healing and better bone integration. During this rapid-fire session, companies will discuss their material platforms, highlighting opportunities and challenges in manufacturing, regulations and new applications.

HAPPE Bone Fusions: Next Generation Bioactive and Porous Polymer Technology

For the first time in our industry’s history, HAPPE’s (HydroxyApatite Porous PEek) porous PEEK technology brings all three fusion elements of material, porosity and bioactivity together into one solution. The strength and modulus of PEEK, the macro and micro surface features of porosity and the bioactivity of hydroxyapatite (HA) exposed on all surfaces throughout the device. Current materials available to surgeons and engineers offer only one or two of these elements. HAPPE brings the next generation of material, capable of exactly replicating the structure and function of the bone it is replacing.

ZFUSE: The First Immuno-stealth Polymer Engineered for Orthopedics and Spine

A major concern across virtually every sector of medicine is host rejection of medical implants, which is often dependent on the immune response. Implants that can harness a positive immune reaction or elicit a favorable immunomodulation will advance the next generation of orthopedic devices by achieving shortened healing timelines, aiding recovery and actively fighting infections which can no longer be colonized. ZFUZE is the first synthetic biomaterial to have tested positively from a favorable immunomodulation standpoint, wherein the immune system, and specifically the macrophages, switch from an early M1 pro-inflammatory phenotype to a M2 pro-healing state. This switch kickstarts the healing and recovery process and positively affects the differentiation of localized stem cells into bone cells with the ZFUZE biomaterial. This positive immune cascade also aids in the maturation and differentiation of bone cells or osteoblasts into laying down mature bone, thereby shortening healing timelines by facilitating quicker fusion.

Check back for more abstracts

Learning Objectives

  • Knowledge of next-generation materials in research and on the market

  • Problems that newly modified materials tend to solve

  • Future applications for new materials


Matt Poggie

Senior Vice President, Regulatory and Quality,

Acuitive Technologies


Doug Snell

Engineering & Program Director,


Sriram Sankar

Director of R&D,

DiFusion Technologies